Arginine biodegradable PAMAM dendrimers (E-PAM-R) as a safe and efficient gene delivery carrier in the field of gene therapy has great value; folic acid modification of the fifth generation polyamido-amine dendrimer (G5-PAMAM-D-fol) , as a gene carrier of suicide gene therapy for prostate cancer is feasible. Weihai CY Dendrimer Technology Co.,Ltd forwards from “Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity” Hye Yeong Nam a, 1, Kihoon Nam a, 1, Hwa Jeong Hahn a, Bo Hye Kim a, Hyun Jung Lim a, Hyun Jin Kim a , Joon Sig Choi b, Jong-Sang Park Seoul National University (a) Chungnam National University (b) (Chungnam National University) Biomaterials 30 (2009) 665-673; “Folic acid modified G5-PAMAM-D vector-mediated suicide gene therapy for prostate cancer HSV-TK/GCV vitro study,” Yue Chen , Deling Kong etc., Tianjin Medical University Second Hospital of Tianjin Institute of Urology, College of Life Research Institute “Chinese scientific papers online.”